| 主权项 |
1. A method for preparing a 2,2-difluoroethylamine of formula (III) comprising reacting 2,2-difluoroethylamine of formula (I) with a halide of formula (II) wherein Hal is chlorine, bromine or iodine, in the presence of diisopropylethylamine, wherein, in the formulae (II) and (III) A is a pyrid-2-yl, pyrid-4-yl or pyrid-3-yl radical each of which may be substituted in the 6-position by fluorine, chlorine, bromine, methyl, trifluoromethyl or trifluoromethoxy or is pyridazin-3-yl, which may be substituted in the 6-position by chlorine or methyl, or is a pyrazin-3-yl, 2-chloropyrazin-5-yl or 1,3-thiazol-5-yl radical, which may respectively be substituted in the 2-position by chlorine or methyl, or is a pyrimidinyl, pyrazolyl, thiophenyl, oxazolyl, isoxazolyl, 1,2,4-oxadiazolyl, isothiazolyl, 1,2,4-triazolyl or 1,2,5-thiadiazolyl radical, which may be substituted by fluorine, chlorine, bromine, cyano, nitro, C1-C4-alkyl optionally substituted by fluorine and/or chlorine, C1-C3-alkylthio optionally substituted by fluorine and/or chlorine, or C1-C3-alkylsulphonyl optionally substituted by fluorine and/or chlorine, or is a pyrid-3-yl of the following formulawherein
X is fluorine, chlorine, bromine, iodine, C1-C6-alkyl or C1-C6-haloalkyl and Y is fluorine, chlorine, bromine, iodine, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, azido or cyano. |
