发明名称 |
IDENTIFICATION OF ANTI-CANCER COMPOUNDS AND COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE AND METHODS OF TREATMENT THEREOF |
摘要 |
Small molecule screening via high-throughput screening (HTS) methods was employed to identify compounds useful for treating or preventing cancer (such as compounds that enable cells to overcome E6-oncoprotein-mediated drug resistance) or neurodegenerative disorders (such as Huntington's disease, HD). Compounds were identified that potentiate the lethality of anti-tumor agents as well as rescue a disease-state lethality. These compounds are acylated secondary amines referred to herein as indoxins and revertins.
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申请公布号 |
US2010022637(A1) |
申请公布日期 |
2010.01.28 |
申请号 |
US20060992867 |
申请日期 |
2006.09.29 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
STOCKWELL BRENT R.;SMUKSTE INESE |
分类号 |
A61K31/35;A61K31/16;A61P25/28;A61P35/04;C07D315/00;C12N5/02;G01N33/00 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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