Drug-conjugates with a targeting molecule and two different drugs
摘要
There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.
申请公布号
AU2014337317(A1)
申请公布日期
2016.09.15
申请号
AU20140337317
申请日期
2014.10.15
申请人
SORRENTO THERAPEUTICS INC.
发明人
MIAO, ZHENWEI;CHEN, GANG;ZHU, TONG;KHASANOV, ALISHER B.;HONG, YUFENG;CHUCHOLOWSKI, ALEXANDER;ZHAN, HONG