| 发明名称 |
EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS |
| 摘要 |
Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving &bgr;-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling. |
| 申请公布号 |
EP3022206(A4) |
申请公布日期 |
2017.03.01 |
| 申请号 |
EP20140826591 |
申请日期 |
2014.07.17 |
| 申请人 |
The Hong Kong University of Science and Technology |
发明人 |
IP, Nancy Yuk Yu;FU, Kit Yu;IP, Fanny Chui Fun;FU, Wing Yu;GU, Shuo;HUANG, Xuhui;HUNG, Kwok Wang |
| 分类号 |
C07D471/20;A61K31/352;A61K31/402;A61K31/403;A61K31/407;A61K31/437;A61K31/438;A61P25/16;A61P25/22;A61P25/24;A61P25/28;A61P35/00 |
主分类号 |
C07D471/20 |
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