Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same

摘要

Compositions of matter and methods for making, storing and administering artificial blood substitutes. Artificial blood substitutes may have oxygen carriers that encapsulate an oxygen-binding compound in a polymer vesicle. Oxygen-binding compounds may include hemoglobin, myoglobin, or other oxygen binding compounds having characteristics similar to hemoglobin. Oxygen carriers may include nanoparticles, polymers and/or polymersomes comprising of poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) and related diblock copolymers of poly(ethylene oxide)-block-poly(γ-methyl ε-caprolactone) (PEO-b-PMCL). The oxygen carriers may have tunable oxygen-binding capacities, uniform and appropriately small size distributions, and human bloodlike viscosities and oncotic properties.

主权项

1. An oxygen carrier composition, comprising:
a plurality of polymers; an oxygen-binding compound containing at least one of a heme group or myoglobin subunit; and at least one allosteric effector comprising a molecule that modifies oxygen binding through at least one of hydrogen ions, carbon dioxide, or 2,3-bisphosphoglycerate.