发明名称 |
Signal transduction pathway modulation |
摘要 |
Provided herein are methods and compositions for modulating signal transduction pathways by regulating the expression and/or activity of Midline-1, enabling the inhibition of airways inflammation, the inhibition of airways hyperresponsiveness, the inhibition of rhinovirus-associated inflammation, and reductions in cytokine and chemokine release. Methods and compositions disclosed herein facilitate the treatment and prevention of conditions associated with airway inflammation, airway tissue remodelling and rhinovirus-associated inflammation and symptoms, manifestations and exacerbations thereof, in particular of allergic diseases such as allergic airways diseases including asthma. |
申请公布号 |
AU2011331905(B2) |
申请公布日期 |
2016.05.12 |
申请号 |
AU20110331905 |
申请日期 |
2011.11.15 |
申请人 |
NEWCASTLE INNOVATION LIMITED |
发明人 |
MATTES, JOERG;FOSTER, PAUL STEPHEN;COLLISON, ADAM;HATCHWELL, LUKE |
分类号 |
A61P37/08;A61K31/395;A61K31/7105 |
主分类号 |
A61P37/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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