发明名称 |
COMPOUNDS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION FOR IMPROVING A DIABETIC PROFILE |
摘要 |
Provided herein are improved compounds, compositions and associated methods for reducing expression of ApoCIII mRNA and protein in a subject having, or at risk of having, diabetes. Also provided herein are compounds, compositions and associated methods improving peripheral insulin sensitivity, a lipid profile and a diabetes profile as well as reducing free fatty acids and intramyocellular triglyceride deposition. |
申请公布号 |
EP3011026(A2) |
申请公布日期 |
2016.04.27 |
申请号 |
EP20140813708 |
申请日期 |
2014.06.23 |
申请人 |
IONIS PHARMACEUTICALS, INC. |
发明人 |
CROOKE, ROSANNE, M.;ALEXANDER, VERONICA, J. |
分类号 |
C12N15/113;A61K31/713;A61P3/10 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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