| 发明名称 |
CONTINUOUS FLOW CARBOXYLATION REACTION |
| 摘要 |
The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield. |
| 申请公布号 |
US2016090361(A1) |
申请公布日期 |
2016.03.31 |
| 申请号 |
US201514866085 |
申请日期 |
2015.09.25 |
| 申请人 |
SARCODE BIOSCIENCE INC. |
发明人 |
Tweedie Scott;Venkatraman Sripathy;Liu Shuhong;Zeller James;Brot Elisabeth;Hamlin Michael;Newman Mary;McLaws Mark;Rosenberg John;Lathbury David |
| 分类号 |
C07D217/04;B01J19/24 |
主分类号 |
C07D217/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process of preparing a compound of Formula I:comprising:
reacting a compound of Formula II:with n-BuLi and TMEDA at −78° C. to afford a compound of Formula III: quenching said compound of Formula III with gaseous carbon dioxide to afford a compound of Formula IV:and
treating said compound of Formula IV with HCl to afford the compound of Formula I, wherein said method is performed using continuous flow reaction conditions. |
| 地址 |
Brisbane CA US |
