发明名称 CARM1 INHIBITORS AND USES THEREOF
摘要 Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R1, R1a, R2a, R2b, R2c, R2d, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula: wherein L2, R13, G8, G10, G11, and G12 are as defined herein. Compounds of the present invention are useful for inhibiting CARMl activity. Methods of using the compounds for treating CARMl -mediated disorders are also described.
申请公布号 WO2016044641(A2) 申请公布日期 2016.03.24
申请号 WO2015US50776 申请日期 2015.09.17
申请人 EPIZYME, INC. 发明人 CHESWORTH, RICHARD;MORADEI, OSCAR, MIGUEL;SHAPIRO, GIDEON;JIN, LEI;BABINE, ROBERT, E.
分类号 A61K31/5383;C07D491/06 主分类号 A61K31/5383
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