| 摘要 |
The present invention relates to a novel dicarboximide derivative of berbamine represented by formula I, including, but not limited to, a phthalimide derivative of berbamine and an aromatic heterocyclic dicarboximide derivative of berbamine, or a pharmaceutically acceptable salt thereof, to a process for preparation of the same, to a pharmaceutical composition comprising said compound and to use thereof in manufacture of an antitumor medicament.; |
| 主权项 |
1. A dicarboximide derivative of berbamine of formula (I): wherein, R1 is selected from H, halogen, amino, nitro, cyano, hydroxyl, mercapto, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C1-C6 alkylthio, substituted or unsubstituted C1-C6 alkylamino, and substituted or unsubstituted C3-C7 cycloalkyl; W, X, Y and Z are selected from substituted or unsubstituted methine CH, methylene CH2 and a heteroatom selected from the group consisting of O, N and S, wherein at least two of W, X, Y and Z are CH or CH2; A is selected from a linear or branched, substituted or unsubstituted alkylene —(CH2)n—, optionally being interrupted by a heteroatom selected from the group consisting of O, N, and S, wherein when W, X, Y and Z are all CH, n is an integer from 7 to 15, and under the remaining circumstances, n is an integer from 1 to 15; wherein “substituted” means a substitution by a substituent selected from the group consisting of halogen, amino, nitro, cyano, hydroxyl and mercapto; or a pharmaceutically acceptable salt thereof. |
