Provided herein are methods of preventing and treating polybacterial infections comprising administering an effective amount of an antibody or antigen-binding fragment thereof that specifically binds to an epitope produced by at least one of the bacterium in the polybacterial infection. For example, an antibody that specifically binds to Staphylococcus aureus alpha toxin can be administered to a patient with a polybacterial infection comprising Staphylococcus aureus and Pseudomonas aeruginosa to inhibit the growth of Pseudomonas aeruginosa.
申请公布号
WO2015196011(A1)
申请公布日期
2015.12.23
申请号
WO2015US36576
申请日期
2015.06.19
申请人
MEDIMMUNE, LLC
发明人
SELLMAN, BRET;HILLIARD, JAMESE, JOHNSON;JONES, OMARI;STOVER, CHARLES, KEN