Factor VIIa inhibitor

摘要

The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

主权项

1. A method of effecting clotting in an individual in need thereof, comprising administering to the individual an isolated compound of Formula Ib: or a zwitterion thereof or a pharmaceutically acceptable salt thereof; substantially free of the opposite enantiomer of the compound of Formula Ib.