Demonstrable Efficacy Across or Within Patient Populations

摘要

The present invention provides methods for improving observed or determined efficacy by administration of agents to more severely diseased subjects, as contrasted with less severely diseased subjects. The present disclosure specifically demonstrates that, with respect to treatment of certain skin conditions, and particularly conditions associated with dysregulated and/or diseased skin cells, administration to more severely diseased subjects improves observed or determined efficacy.

主权项

1. A method of improving demonstrable effectiveness of a treatment, the method comprising steps of:
a) determining stratification of subjects into two or more categories based on disease or condition severity, so that a first category corresponds to relatively severe disease or condition relative to at least one second category; and b) administering the treatment to subjects in the first category and not to subjects in at least one second category.