发明名称 |
BROAD SPECTRUM BETA-LACTAMASE INHIBITORS |
摘要 |
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections. |
申请公布号 |
CA2935651(A1) |
申请公布日期 |
2009.04.16 |
申请号 |
CA20082935651 |
申请日期 |
2008.10.09 |
申请人 |
GLADIUS PHARMACEUTICALS CORPORATION |
发明人 |
SUTTON, LARRY;YU, SOPHIA |
分类号 |
C07D501/24;A61K31/546;A61P31/04;C07D501/22 |
主分类号 |
C07D501/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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