Device and method for creating aerosols for drug delivery

摘要

A drug delivery device is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device includes a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel is surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled from an opening. The opening from which the gas is expelled is positioned directly in front of the flow path of liquid expelled from the feeding channel. Various parameters are adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exits the pressure chamber opening and is aerosolized into particles having a uniform diameter in the range of about 1 to 5 microns.