发明名称 |
HIGH RESOLUTION MELTING ANALYSIS AS A PRESCREENING TOOL |
摘要 |
Compositions and methods for determining an increased likelihood of a response to a targeted treatment of a cancer disease including isolating genomic DNA from a patient sample, amplifying a fragment of DNA by means of PCR with a specific pair of amplification primers, determining if the amplified fragment comprises a wildtype sequence or a mutation by means of a High Resolution Melting Analysis (HRM), and correlating the presence or absence of a mutation with an increased likelihood of success of said targeted treatment. Respective primer pairs, compositions and kits are also claimed. |
申请公布号 |
EP2663652(A1) |
申请公布日期 |
2013.11.20 |
申请号 |
EP20120701078 |
申请日期 |
2012.01.09 |
申请人 |
ROCHE DIAGNOSTICS GMBH;F.HOFFMANN-LA ROCHE AG |
发明人 |
BUETTNER, REINHARD;FROEHNER, STEFANIE;MERKELBACH-BRUSE, SABINE;NEY, JASMIN;ROESLER, ANGELIKA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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