| 摘要 |
The present disclosure provides methods for increasing or decreasing T cell activation. The methods include contacting a T cell with an miRNA nucleic acid or an inhibitor of an miRNA. In some embodiments, the disclosed methods for increasing T cell activation include activating a T cell and contacting the activated T cell with an effective amount of an miRNA nucleic acid (such as one or more of miR-21, miR-101a, miR-377, let-7b, let-7c, or miR-574); or an inhibitor of an miRNA (for example, an inhibitor of one or more of miR-99a, miR-467b, miR- 467d, miR-199a, or miR-192), thereby increasing T cell activation, for example as compared to a control. In other embodiments, the disclosed methods for decreasing T cell activation include contacting a T cell (such as an activated T cell) with an effective amount of an inhibitor of an miRNA (for example, an inhibitor of one or more of miR-21, miR-101a, miR-377, let-7b, let-7c, or miR-574); or an miRNA nucleic acid (such as one or more of miR-99a, miR-467b, miR-467d, miR-199a, or miR-192), thereby decreasing the T cell activation, for example as compared to a control. |
