发明名称 |
Method of Providing Sustained Analgesia With Buprenorphine |
摘要 |
A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in accordance with substantially zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.
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申请公布号 |
US2011288112(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
US20100888298 |
申请日期 |
2010.09.22 |
申请人 |
REDER ROBERT F.;GOLDENHEIM PAUL D.;KAIKO ROBERT F. |
发明人 |
REDER ROBERT F.;GOLDENHEIM PAUL D.;KAIKO ROBERT F. |
分类号 |
A61K31/46;A61F13/00;A61K9/22;A61K9/70;A61K31/00;A61K31/485;A61P25/00;A61P29/00 |
主分类号 |
A61K31/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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