发明名称 |
Ethyl 3-[(2-{[4-Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionate methanesulfonate hemihydrate and its use as a medicament |
摘要 |
<p>Ethyl 3-(N-(2-(4-(hexyloxycarbonylamidino)phenyl aminomethyl)-1-methyl-1H-benzimidazole-5-carbonyl)-N-(2-pyridyl)amino )propionate methanesulfonate polymorph I (Ia), polymorph II (Ib) and hemihydrate (Ic), with melting points of 180 plus or minus 3 deg. C, 190 plus or minus 3 deg. C and 120 plus or minus 5 deg. C respectively, are new. - Independent claims are also included for the preparation of (Ia)-(Ic). - ACTIVITY - Anticoagulant; Cerebroprotective; Vasotropic. - No biological data is given. - MECHANISM OF ACTION - Thrombin inhibitor.</p> |
申请公布号 |
EP2060569(B1) |
申请公布日期 |
2011.10.19 |
申请号 |
EP20090153155 |
申请日期 |
2004.08.24 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
SIEGER, PETER;SOBOTTA, RAINER;SCHMID, ROLF |
分类号 |
C07D401/12;A61K31/4439;A61P7/02 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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