1-SUBSTITUTED-TRANS-3-(SUBSTITUTED AMINO)PIPERIDIN-4-OL

摘要

Disclosed is a 1-substituted-trans-3-(substituted amino)piperidin-4-ol which is useful for various chemical products such as a pharmaceutical intermediate. The 1-substituted-trans-3-(substituted amino)piperidin-4-ol is obtained by a method for producing a 1-substituted-trans-3-(substituted amino)piperidin-4-ol represented by formula (IV-1), said method comprising a step wherein a 1-substituted-3,4-epoxypiperidine represented by formula (I) (wherein R1 represents an aryl group, an alkyl group which may be substituted by an aryl group and has 1-12 carbon atoms, or the like) and an amine compound represented by formula (II) (wherein A1 and A2 each represents an aryl group, an alkyl group which may be substituted by an aryl group and has 1-12 carbon atoms, or the like) are caused to react with each other in a solvent.