发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVATION OF DSRNA-DEPENDENT PROTEIN KINASE AND TUMOR GROWTH INHIBITION |
摘要 |
The present invention relates to compositions and methods for preventing and treating a condition in a mammalian subject that include at least one inhibitor of double stranded RNA dependent protein kinase (PKR-I) prior to or concurrently with the treatment, wherein the treatment results to an inhibition of activation of dsRNA-dependent protein kinase. The compositions and methods of the present invention further include at least one potentiator that further enhances the inhibition of phosphorylation by PKR-I.
|
申请公布号 |
US2011077198(A1) |
申请公布日期 |
2011.03.31 |
申请号 |
US20080743312 |
申请日期 |
2008.10.03 |
申请人 |
TISDALE MICHAEL JOHN;ELEY HELEN LAURA;RUSSELL STEVE THOMAS;MILLER KEVIN BURKE |
发明人 |
TISDALE MICHAEL JOHN;ELEY HELEN LAURA;RUSSELL STEVE THOMAS;MILLER KEVIN BURKE |
分类号 |
A61K38/18;A61K31/198;A61K31/20;A61K31/353;A61K31/70;A61K31/7088;A61K38/00;A61P3/10;A61P9/00;A61P11/00;A61P17/00;A61P31/18;A61P35/00;A61P37/00 |
主分类号 |
A61K38/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|