Amides of n-acyl-cysteines mucolytic agents

摘要

Cpds. of general formula : (I) R1,R2 = H, alkyl C1-C4 R3 = H, alkyl, aralkyl or aryl, each C is not > 9 R4 = H, alkyl C1-C5, alkenyl C2-C5, cycloalkyl C is not > 5, cycloalkenyl C is not > 5, each opt. substd. by 1 or 2 OH gps. R5 = H or alkyl C1-C4 opt. substd. by 1 or 2 OH gps. NHR4R5 may be piperidino, pyrrolidino,N'-R5-piperazino, morpholino, thiamorpholino or hexa-methyleneimino. Mucolytic agents.