摘要 |
Provided herein are tetracyclic 1H-indeno[1,2-b]pyridine-2(5H)-one analogs and derivatives, compositions comprising an effective amount of a tetracyclic 1H- indeno[1,2-b]pyridine-2(5H)-one analog and/or derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, a reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, an ocular or ophthalmologic disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, contrast induced nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of a tetracyclic 1H- indeno[1,2-b]pyridine-2(5H)-one analog or derivative. |
申请人 |
INOTEK PHARMACEUTICALS CORPORATION;JAGTAP, PRAKASH;PHAM-HUU, DUY-PHONG;COHEN, FREDERICK;HU, HUIYONG;WANG, XIAOJING |
发明人 |
JAGTAP, PRAKASH;PHAM-HUU, DUY-PHONG;COHEN, FREDERICK;HU, HUIYONG;WANG, XIAOJING |