发明名称 |
POLYMER CONJUGATE OF FOLIC ACID OR FOLIC ACID DERIVATIVE |
摘要 |
Disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein an amide bond is not used. The compound has chemical stability and adequate drug release rate in the living organism. Specifically disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein a substituent represented by formula (I) is bonded to a carboxy group of a block copolymer which is composed of a polyethylene glycol and a polymer having a carboxy group in a side chain, or a pharmacologically acceptable salt thereof. [In the formula, A represents a monocyclic or fused aromatic group; G represents an optionally substituted (C1-C6) alkylene group; Y represents a hydrogen atom or a substituent; and E represents a residue of folic acid or a folic acid derivative.] |
申请公布号 |
WO2009136572(A1) |
申请公布日期 |
2009.11.12 |
申请号 |
WO2009JP58325 |
申请日期 |
2009.04.28 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA;NAKANISHI TAKESHI;HARA KAZUHISA;SENO CHIEKO |
发明人 |
NAKANISHI TAKESHI;HARA KAZUHISA;SENO CHIEKO |
分类号 |
C08G69/40;A61K31/517;A61K31/519;A61K47/48;A61P29/00;A61P35/00;C08G81/00 |
主分类号 |
C08G69/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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