| 摘要 |
This invention is related to an MMP- 9 inhibitor which contains chlorogenic acid (CHA; 5-caffeoylquinic acid). Matrix metalloproteinase-9 inhibitors represent the best candidates for achieving tumor regression. Thus the invention is disclosed a chlorogenic acid, especially isolated from the Euonymus alatus, having a anti-MMP-9 activity. CHA showed strong inhibitory effect of MMP-9 activity in a concentration-dependent manner. The CHA showed cytotoxic effect on the hepatocarcinoma cellular proliferation and cell viability. |
