NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES.

摘要

Use of a pyrido[3',2':4,5]thieno[3,2-d]pyrimidine derivative of formula (I), wherein n is an integer selected from 0 or 1 R1 and R2are independently selected from hydrogen atoms and C1-4 alkyl groupsR3 represents a group selected from alkyl, amino, monoalkylamino,dialkylamino, aryl, heteroaryl and saturated N-containing heterocyclyl groupsbound through the nitrogen atom to the piridine ring, all of them being optionallysubstituted by one or more substituents selected from the group consisting ofhalogen atoms and alkyl, alkoxyalkyl, arylalkyl, R6000-, alkoxy,R6R7N-CO-, -CN, -CF3, -NR6R7,-SR6 and - SO2NH2 groups wherein R6and R7 are independently selected from hydrogen atoms and C1-4alkyl groups R4 and R5 are independently selected from thegroup consisting of hydrogen atoms, alkyl groups and groups of formula (II):wherein p and q are integers selected from 1, 2 and 3; A is either a direct bond ora group selected from -CONR12-, -NR12CO-, -O-, -COO-, -OCO-,-NR12COO-, -OCONR12-, -NR12CONR13 -,-S-, -SO-, -SO2-, -COS- and -SCO-; and G2 is a group selectedfrom aryl, heteroaryl or heterocyclyl; wherein the alkyl groups and the groupG2 are optionally substituted by one or more substuents selected fromgroup consisting of halogen atoms and alkyl, alkoxyalkyl, arylalkyl, R14OCO-,hydroxy, alkoxy, oxo, R14R15N-CO-, -CN, -CF3,-NR14R15, -SR14 and -SO2NH2groups; wherein the groups R8 to R15 are independently selectedfrom hydrogen atoms and C1_4 alkyl groups; andthe pharmaceutically acceptable salts and N-oxides thereof; in the manufactureof a medicament for the treatment or prevention of a pathological condition ordisease susceptible to amelioration by inhibition of phosphodiesterase 4.