Carbamic acid compounds comprising an amide linkage for the treatment of malaria

摘要

This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: <CHEM> wherein: A is an aryl group; Q<1> is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: -NR<1>C(=O)- and -C(=O)NR<1>-; R<1> is an amido substituent; and, Q<2> is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof, for use in the treatment of parasitic infections, such as malaria.