2-Alpha vitamin D derivatives having substituents

摘要

An object of the present invention is to synthesize a novel vitamin D₃ derivative having a substituent at the 2alpha-position. The present invention provides vitamin D derivatives represented by-Formula (I): wherein R¹ represents a saturated aliphatic C_1-15hydrocarbon group optionally substituted with 1 to 3 hydroxy or protected hydroxy groups; and R² represents a saturated aliphatic C_1-10hydrocarbon group optionally substituted with one or more substituents, which may be the same or different and which are selected from the group consisting of a hydroxy group, a halogen atom, a cyano group, a lower alkoxy group, an amino group and an acylamino group, provided that when R² represents a saturated aliphatic C₁hydrocarbon group, R² is substituted with at least one substituent.