发明名称 |
System for directed molecular interaction in surface plasmon resonance analysis |
摘要 |
Disclosed is apparatus and method for controlled surface plasmon resonance analysis having a surface plasmon resonance sensor (200) with a derivatized surface plasmon layer (116) in optical communication with the sensor, derivatizing the surface plasmon layer and placing an analyte detection chamber (102) in fluid communication with the derivatized surface plasmon layer. The chamber is adapted (118, 120) for the generation of a molecular interaction bias across the chamber. A conjugate is provided between an analyte and a bias responsive element, wherein the analyte is reactive with the derivatized surface plasmon layer and the bias responsive element changes the response of the analyte to the molecular interaction bias. A conjugated analyte may be introduced into the chamber, generating a molecular interaction.
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申请公布号 |
US6870627(B2) |
申请公布日期 |
2005.03.22 |
申请号 |
US20030693449 |
申请日期 |
2003.10.27 |
申请人 |
TEXAS INSTRUMENTS INCORPORATED |
发明人 |
ELKIND JEROME L.;STRONG ANITA A.;HUEHMER ANDREAS |
分类号 |
G01N21/05;G01N21/55;(IPC1-7):G01N27/26;G01N21/76 |
主分类号 |
G01N21/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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