发明名称 |
Osteoarthritis cartilage regeneration |
摘要 |
For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: (1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); (2) broaden the suitable clinical population to routinely include middle-aged patients; (3) eliminate the use of autologous tissue grafts (mature cartilage and the periosteal covering) to repair an articular cartilage injury; (4) regenerate other types of injured cartilage such as patellar and spinal disk cartilage; (5) regenerate articular joint cartilage in older patients with osteoarthritis; and (6) form new cartilage and subchondral bone which fully integrate into the adjacent normal tissue.
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申请公布号 |
US6835377(B2) |
申请公布日期 |
2004.12.28 |
申请号 |
US19980078531 |
申请日期 |
1998.05.13 |
申请人 |
OSIRIS THERAPEUTICS, INC. |
发明人 |
GOLDBERG VICTOR M.;CAPLAN ARNOLD I.;BARRY FRANCIS P.;FINK DAVID J.;MARSHAK DANIEL R.;BURNS JAMES S. |
分类号 |
A61K35/12;C12N5/077;C12N5/0775;(IPC1-7):C12N5/00 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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