VACCINE ACCELERATOR FACTOR (VAF) FOR IMPROVEMENT OF VACCINATIONS IN POULTRY

摘要

The present invention provides a vaccine accelerator factor (VAF) which is a n in ovo nucleotide immuno-stimulant. The VAF contains one or more DNA constructs, each having a DNA molecule and a vector. Each of the DNA molecul e contains one or more genes or gene fragments, each encoding an antigenic peptide of an avian virus. The VAF is preferably administered to the amnioti c fluid of an egg after being fertilized for about 17-19 days. The VAF can be co- administered with a viral vaccine containing one or more attenuated or inactive avian viruses. Alternatively, the VAF can be administered prior to the administration of the viral vaccine, which is administered at hatch or post-hatch. The VAF stimulates and accelerate a protective immune response o f a viral vaccine.