发明名称 |
Antisense modulation of novel anti-apoptotic bcl-2-related proteins |
摘要 |
Compositions and methods are provided for modulating the expression of novel anti-apoptotic bcl-2-related proteins. Antisense oligonucleotides targeted to nucleic acids encoding the human novel anti-apoptotic bcl-2-related proteins A1 and mcl-1 are preferred. Methods of using these compounds for modulation of novel anti-apoptotic bcl-2-related protein expression and for treatment of diseases associated with expression of novel anti-apoptotic bcl-2-related proteins are also provided. Also provided are methods of using these compounds for promoting apoptosis and for treatment of diseases for which promotion of apoptosis is desired.
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申请公布号 |
US2004204380(A1) |
申请公布日期 |
2004.10.14 |
申请号 |
US20040844470 |
申请日期 |
2004.05.12 |
申请人 |
ACKERMANN ELIZABETH J;BENNETT C FRANK;DEAN NICHOLAS M;MARCUSSON ERIC G |
发明人 |
ACKERMANN ELIZABETH J;BENNETT C FRANK;DEAN NICHOLAS M;MARCUSSON ERIC G |
分类号 |
C12N15/113;(IPC1-7):A61K48/00;C07H21/04 |
主分类号 |
C12N15/113 |
代理机构 |
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