DETECTING THE RISK OF CARDIOVASCULAR DISEASES BY DETECTING MUTATIONS IN GENES, INCLUDING GENES ENCODING a2b-ADRENOCEPTOR AND APOLIPOPROTEIN B

摘要

The present invention provides a method of identifying subject's susceptibility to cardiovascular diseases or risk of developing myocardial infarction (MI) or cerebrovascular stroke by detecting gene polymorphisms and other gene mutations from a biological sample of the subject and optionally obtaining information concerning the family and medical history, blood, serum, plasma and urinary analytes of the subject. Genetic variations or polymorphisms are detected in a number of genes, including genes encoding a2b-adrenoceptor and apolipoprotein B. The invention also provides a multivariate model, a combination or algorithm of variables which best describes the probability of cardiovascular diseases especially MI and stroke. The invention also relates to a test kit and software for accomplishing the method.