| 摘要 |
This invention provides compounds having the structurewhereinA is OR<5>, orR<1 >is alkyl, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl,R<2 >is H, alkyl, or aryl; R<3 >and R<4 >are halo, H, alkyl, aryl, trifluoromethyl, alkoxyaryl, nitro, amino, carboalkoxy, carbamide, carbamate, urea, alkylsulfonamide, -NR<7>(CH2)mCO2H, arylsulfonamide, cycloalkyl, or a heterocycle; R<5 >is H, alkyl, -CH(R<8>)R<9>, -CH2(CH2)nCO2R<10>, -C(CH3)2CO2R<10>, -CH(R<8>)(CH2)nCO2R<10>, -CH(R<8>)C6H4CO2R<10>, or -CH2-tetrazole; R<6 >is H, alkyl, halo, alkoxy, trifluoroalkyl or trifluoroalkoxy; R<7 >is H or alkyl; R<8 >is H, alkyl, aryl, arylalkyl, cycloalkyl, phthalic acid,R<9 >is CO2R<12>, CONHR<12>, tetrazole, or PO3R<12>; R<10 >is H, alkyl, aryl, or aralkyl;R<11 >is alkyl; R<12 >is H, alkyl, aryl, or aralkyl; X is O, or S; Y is O, N, or S; Z is C, or N;Q is O, N, or S; m=1-3; n=1-6, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
|
