| 发明名称 |
NUCLEIC ACID MUCOSAL IMMUNIZATION |
| 摘要 |
<p>Mucosal delivery of antigens using, for example, a replication-defective gen e delivery vehicle, particularly replication-defective alphavirus vectors and particles, is described. Also described are compositions comprising a mucosa l adjuvant and one or more antigens derived from HIV. Also provided is the use of these gene delivery vehicles in inducing mucosal, local and/or systemic immune responses following mucosal immunization regimes.</p> |
| 申请公布号 |
CA2434546(A1) |
申请公布日期 |
2002.10.17 |
| 申请号 |
CA20022434546 |
申请日期 |
2002.01.14 |
| 申请人 |
CHIRON CORPORATION |
发明人 |
POLO, JOHN;VAJDY, MICHAEL;DUBENSKY, THOMAS JR.;O'HAGAN, DEREK |
| 分类号 |
A61K48/00;A61K35/76;A61K38/00;A61K39/00;A61K39/02;A61K39/095;A61K39/118;A61K39/12;A61K39/21;A61K39/245;A61K39/29;A61P1/16;A61P31/04;A61P31/12;A61P31/18;A61P31/22;A61P37/04;A61P43/00;C12N15/86;(IPC1-7):A61K48/00 |
主分类号 |
A61K48/00 |
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