ACTIVITY-DEPENDENT CYSTEINE PROTEASE PROFILING REAGENT

摘要

Probes are provided having specificity for papain cysteine hydrolases comprising an electrophile, exemplified by an epoxide, a hydrophobic group for fitting into the hydrolase pocket and a moiety that provides for detection and/or isolation. A variety of compound having hydrophobic side chains form an oligopeptide are exemplified using fluorescers, ligand members of specific binding pairs or radioactive labels for detection and/or isolation.