发明名称 |
XYLOSYLTRANSFERASE AND ISOFORMS THEREOF |
摘要 |
The invention relates to the isolation, purification and characterization of the enzyme xylosyltransferase (defined as "XT"). The invention describes for the first time that XT occurs in at least two isoforms ("XT-I", "XT-II"). The invention relates furthermore to the recombinant cloning and expression of human and rat XT-I and XT-II and discloses their DNA and protein sequences. The enzymes according to the invention can be used as therapeutic agents and as diagnostic markers, e.g. for the determination of enhanced proteoglycan biosynthesis, and as biochemical markers for determination of several pathological processes such as systemic sclerosis. |
申请公布号 |
WO0149831(A3) |
申请公布日期 |
2002.01.10 |
申请号 |
WO2000EP13311 |
申请日期 |
2000.12.28 |
申请人 |
KLEESIEK, KNUT;BRINKMANN, THOMAS;GOETTING, CHRISTIAN;KUHN, JOACHIM |
发明人 |
KLEESIEK, KNUT;BRINKMANN, THOMAS;GOETTING, CHRISTIAN;KUHN, JOACHIM |
分类号 |
A61K38/00;C12N9/00;C12N9/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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