| 发明名称 |
Fatty-acid amide hydrolase |
| 摘要 |
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary(amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of cis-9,10-octadecenoamide by FAAH leads to the formation of oleic acid, a compound without soporific activity. FAAH has be isolated and the gene encoding FAAH has been cloned, sequenced, and used to express recombinant FAAH. Inhibitors of FAAH are disclosed to block the hydrolase activity.
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| 申请公布号 |
US6271015(B1) |
申请公布日期 |
2001.08.07 |
| 申请号 |
US19960743168 |
申请日期 |
1996.11.04 |
| 申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
GILULA NORTON B.;CRAVATT BENJAMIN F.;LERNER RICHARD A. |
| 分类号 |
C12N15/00;A61K31/12;A61K38/46;A61P25/00;A61P25/20;A61P43/00;C07C45/45;C07C49/227;C07C57/03;C07C233/09;C07C327/22;C07F9/54;C12N9/80;C12N9/99;C12N15/09;C12P7/64;C12Q1/34;(IPC1-7):C12N9/80 |
主分类号 |
C12N15/00 |
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