| 摘要 |
<p>Methods of isolating β(1,3)-glucan or β(1,3)-glucan-containing organisms in a sample, or of detecting the presence of β(1,3)-glucan or β(1,3)-glucan-containing organisms in a sample, utilizing a proteinaceous receptor for underivatized, aqueous soluble β(1,3)-glucan (e.g., an NR8383 receptor) are described. Methods of diagnosing fungal infection, by detecting β(1,3)-glucan or β(1,3)-glucan-containing organisms, are also described. Antibodies and kits useful in the methods are also disclosed. A preparation containing a proteinaceous receptor for underivatized, aqueous soluble β(1,3)-glucan is additionally disclosed, along with characterization of the receptor for underivatized, aqueous soluble β(1,3)-glucan. Also described are assays for identifying agents which alter the effect of underivatized, aqueous soluble β(1,3)-glucan on activation of signal transduction pathways and agents identified thereby.</p> |
