METHODS FOR REGULATING TRKA EXPRESSION

摘要

The current invention provides methods for the upregulation of trkA in a mammal, including humans, comprising the administration of an effective amount of a compound of formula (I), wherein R?1 and R3¿ are, independently, -H, -CH¿3?, -CO(C1-C6 alkyl), or -COAr, where Ar is optionally substituted phenyl; R?2¿ is selected from the group consisting of pyrrolidine, piperidine, and hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof. In addition, the current invention provides method to increase the effect of NGF (Nerve Growth Factor), whether the NGF is from endogenous of exogenous sources. Further, the current invention provides methods for maintaining the homeostasis and health of the hippocampus, hypothalamus, and cortex, thus maintaining their biological functions.