| 摘要 |
A controlled release tablet formulation of isosorbide mononitrate is formed by granulating ISMN with a solution of a polyvinylpyrollidone. The weight ratio of ISMN to water in the solution of granulating aid is from 6:1 to 1:1, preferably approximately 2:1. The dry granules are blended with a cellulose based controlled release agent, the weight ratio of ISMN to controlled release agent being 30:70 to 80:20, preferably approximately 3:2. A tablet is punched out on a 5.5 mm punch to fit a number one capsule which may also contain a second active such as a tablet of coated aspirin. |
