NEUROLEPTIC PERHYDRO-1H-PYRIDO(1,2-a)PYRAZINES, INTERMEDIATES FOR PREPARATION PROCESS THEREOF AND PHARMACEUTICAL COMPOSITION

摘要

Perhydropyrido(1,2-a) pyrazine derivs. of formula (I) and their acid-addn. salts ar new. In (I) X = H, Me or Et; L = CO(CH2)mR; or L+X = a gp. of formula LX1-LX8; r = 1-6c alkyl, 3-7C cycloalkyl, norbornylmethyl, or phenyl, naphthyl, furyl, benzofuranyl, thienyl, benzothienyl, pyrrolyl, indolyl or isoindolyl opt. substd. by F, Cl, Me, Et, OMe or OEt; R1-R3 = H or Me R4 = phenyl opt. substd. by F, Cl, Me, Et, OMe OEt; X1 = CH or N; Y =O or S; Y1 = CH2, S, O or NH; Y2 and Y3 = H or Me, or Y2+Y3 = (CH2)q; Z = H or Cl; m = 0-3; n = 1-4; p = 1 or 2; q = 2-5; r = 0 or 1.