| 摘要 |
PCT No. PCT/EP93/00874 Sec. 371 Date Oct. 17, 1994 Sec. 102(e) Date Oct. 17, 1994 PCT Filed Apr. 8, 1993 PCT Pub. No. WO93/21174 PCT Pub. Date Oct. 28, 1993.A process for the production of sclareolide comprising the steps of: (1) providing an aqueous composition comprised of: (a) water; (b) sclareol, abienol, or a mixture of sclareol and abienol, (c) an effective amount of a ruthenium catalyst; and, (d) an emulsifying agent; (2) forming an aqueous alkaline composition by adding an alkali metal hydroxide to said aqueous composition; (3) reacting said aqueous alkaline composition with an oxidizing agent to form a crude product; and either: (4) further reacting said crude product with base to form the salt of 8 alpha -hydroxy-11-carboxyl-12, 13, 14, 15, 16-pentanorlabdane and; (5) reacting said salt with acid to form sclareolide; or: (4) heating said crude product to form sclareolide.
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