发明名称 |
BICYCLIC FIBRINOGEN ANTAGONISTS |
摘要 |
<p>Certain compounds within formula (I) are inhibitors of platelet aggregation wherein A<1> is NH or CH2; R is H, C1-6alkyl, benzyl or a carboxy protecting group; R<3> is C1-6alkyl, Ar-C0-6alkyl, C3-7cycloalkylC0-6alkyl, or Het-C0-6alkyl; R<6> is 4-amidino-Ar-N(CH3)CO, [[2-(4-piperidinyl)ethyl](N-methyl)amino]carbonyl, (4,4'-bipiperidin-1-yl)carbonyl, [4-(2-aminoethyl)piperidin-1-yl]carbonyl, [[[3-(4-piperidinyl]propyl]methylamino]carbonyl, 1-[4-(4-pyridyl)piperazinyl]carbonyl, [[2-[(2-amino)pyrid-4-yl]ethyl]methylamino]carbonyl, [[2-(4-piperidinyl)ethyl]carbonyl]amino, [[2-(4-piperidinyl)ethyl]carbonyl]amino, [[2-(1-piperazinyl)ethyl]methylamino]-carbonyl, or [[(1,2,3,4-tetrahydro-7-isoquinolinyl]amino]carbonyl; and X is H, C1-4alkyl, C1-4alkoxy, C1-4alkthio, trifluoroalkyl, N(R')2, CO2R', CON(R')2, OH, F, Cl, Br or I.</p> |
申请公布号 |
WO9518619(A1) |
申请公布日期 |
1995.07.13 |
申请号 |
WO1995US00248 |
申请日期 |
1995.01.09 |
申请人 |
SMITHKLINE BEECHAM CORPORATION;BONDINELL, WILLIAM, EDWARD;CALLAHAN, JAMES, FRANCIS;HUFFMAN, WILLIAM, FRANCIS;KEENAN, RICHARD, MCCULLOCH;KU, THOMAS, WEN-FU;NEWLANDER, KENNETH, ALLEN;SAMANEN, JAMES, MARTIN;UZINSKAS, IRENE, NIJOLE |
发明人 |
BONDINELL, WILLIAM, EDWARD;CALLAHAN, JAMES, FRANCIS;HUFFMAN, WILLIAM, FRANCIS;KEENAN, RICHARD, MCCULLOCH;KU, THOMAS, WEN-FU;NEWLANDER, KENNETH, ALLEN;SAMANEN, JAMES, MARTIN;UZINSKAS, IRENE, NIJOLE |
分类号 |
C07D243/24;A61K31/55;A61K31/551;A61P7/02;A61P9/08;A61P9/10;A61P43/00;C07D223/16;C07D243/14;C07D401/06;C07D401/12;C07D401/14;C07D409/06;(IPC1-7):A61K31/55;C07D223/00 |
主分类号 |
C07D243/24 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|