RECOMBINANT 170 KD SUBUNIT LECTIN OF ENTAMOEBA HISTOLYTICA AND METHODS OF USE

摘要

Recombinantly produced 170 kDa heavy subunit of Entamoeba histolytica Gal/GalNAc adherence lectin or an epitope-bearing portion thereof may be used as antigen in serological analysis of E. histolytica infection or as a vaccine for immunizing against infection. The recombinant production is achieved in a procaryotic system to provide non-glycosylated antigens or immunogens which are immunologically reactive. Also disclosed are three genes which encode epitope-bearing portions of the lectin.