New physiologically active substances, probestin and prostatin and production thereof.

摘要

New physiologically active substances, named probestin and prostatin, respectively, are produced from a new microorganism, Streptomyces azureus MH663-2F6 strain identified as FERM P-9541 or FERM BP-1963. Probestin and prostatin have an activity inhibitory to aminopeptidase M and also have immunopotentiating properties. The formula is as follows: <CHEM> wherein R denotes a phenyl group for probestin, or R denotes a 2-methyl-butyl group for prostatin.