| 摘要 |
A controlled release formulation for oral administration comprising - a 9,10-dihydro ergot alkaloid, - a pharmaceutically acceptable hydrophilic swelling substance and - a pharmaceutically acceptable inert fatty material. The alkaloid may be co-dergocrine, dihydroergotamine, epicryptine or 9'-thia-9,10-dihydroergotamine. Suitable swelling agents are cellulose hydrocolloids such as hydropropyl-methylcellulose. The fatty material is preferably a fatty acid ester such as cetyl palmitate. The compositions are particularly useful in treating hypertension and migraine. |
