| 摘要 |
<p>6-Amino 1,2-dihydro 1-hydroxy 2-imino 4-piperidino pyrimidine is made by (a) reaction of 4-amino 6-chloro 2-mercaptomethyl pyrimidine with piperidine under reflux (b) removal of excess piperidine under reduced pressure, filtering off and washing with water; (c) treatment of the 4-amino 6-(1-piperidinyl) 2-methylcercapto pyrimidine formed with ammonia in methanol at 150 deg.C, removal of solvent under reduced pressure and crystallising from 50% alcohol; and (d) oxidn. of the 2,4-diamino 6-(1-piperidinyl) pyrimidine obtained with peracetic acid (40% in alcohol) at reflux temp..</p> |
