| 摘要 |
<p>1-N-[L-(-)-w-amino-α-hydroxy alkanoyl kanamycins(I; R = OH, NH2; n = 0,1,2; B = amino protective group), useful as antibiotic substance, were prepd. by acylating polysilated kanamycins A or B with acylate derivs. of acid(II) in anhydrous organic solvent followed by eliminating other protective group. Thus, the soln. of anhydrous acetone 10 ml and L-(-)-γ-benzyloxycarbonylamino-α-hydroxy butylic-N-hydroxy-5-norbornene-2,3-dicarboxy imide ester 2 millimol was added in the soln. of anhydrous acetone 30 ml and poly(trimethylsilyl) kanamycin A 2.4 g (2 millimol) and then stirred at 23≰C for a week to give compd. (I).</p> |
