Composition for reducing nervous system injury and method of making and use thereof

摘要

This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.

主权项

1. A method for reducing nerve injury in an adult human subject, comprising:
administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride or a pharmaceutically acceptable salt thereof; wherein the pharmaceutical composition is administered intravenously within five hours of the onset of an ischemic event and wherein the nerve injury is acidosis-induced nerve injury.